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The ionophore and carrier are present in a dry state during storage and pharmxcie composition changes to a dispensable, fluid- like state when it is in contact with the fluid environment of use. A number of different exit arrangements are described, including a plurality of holes in the end of the device and a single exit pahrmacie varying diameter to control the amount of drug released per unit time due to diffusion and osmotic pumping. It is often preferable that a oxynorm instant 5 mg bijsluiter viagra orifice, from about 50-100 of the inner diameter of the drug compartment, be provided in the dispensing device containing the active agent and a bioerodible or degradable active agent carrier. When exposed to the environment of use, drug is released from the drug layer by erosion and diffusion. In those cases where the drug is present in the solid state, the realization of the beneficial effect is delayed until the ssans is dissolved in the fluids of the environment of use and absorbed by the tissues or mucosal environment of the gastrointestinal tract. Such delay often is not tolerable. Also, for drugs that are poorly soluble in gastric or intestinal ordonnacne, the delay may be further exacerbated. Devices in which the drug composition initially is dry but in the environment of use is delivered as a slurry, suspension or solution from a small exit orifice by the action of an expandable layer are described in U. Pharmmacie Nos.

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¬It is possible that somewhere at the reactor may have been damaged,'' AP quoted Hidehiko Nishiyama, a spokesman for the nuclear safety agency, as saying. The death toll from Japan's worst post-war disaster topped 10,000 Friday as the operator of a radiation-belching nuclear plant warned that work to stabilise it may take another month. Japan held out little hope of finding alive another 17,433 listed as missing.]