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Product Description

Examples of additional polymers for the formulation of the push- displacement composition comprise osmopolymers comprising polymers that form hydrogels, such as Carbopol acidic carboxypolymer, a polymer of acrylic cross-linked with a polyallyl sucrose, also known as carboxypolymethylene, and carboxyvinyl polymer having a molecular weight of 250,000 to 4,000,000; Cyanamer 9 polyacrylamides; cross-linked condroitinz swellable. ¬ mdenemaleic anhydride polymers; Good-rite polyacrylic acid canottaggio olimpiadi viagra side a molecular weight of 80,000 to 200,000; Aqua-Keeps acrylate polymer polysaccharides composed of condensed glucose units, such as diester cross-linked polygluran; and the like. Representative polymers that form hydrogels glucosamina condroitina msm efeitos colaterais do viagra known to the prior art in U. Patent No. 3,865,108, issued to Hartop; U.

For example, if the conventional dosage form contains 200 mg of active agent and is to be administered every 3 hours, a dosage form of this glucosamina condroitina msm efeitos colaterais do viagra may be prepared for administration every 6 hours, and that dosage form may contain 400 mg of active agent which will be delivered over the 6 hour period. However, when compliance with multiple dosing is a problem, the advantage of administering the dosage forms of the invention at fewer times throughout a twenty-four hour period may provide incentive to incorporate greater amounts of active agent, where such greater amounts do not have any deleterious effects. The specific amount of active agent to be included in the dosage form of the invention can easily be determined by routine dosage studies that compare the blood plasma active agent levels of subjects with conventional dosing and the dosage form of this invention. The dosage forms of this form of the invention can conveniently release active agent in a controlled and sustained manner over a prolonged period. Typically, active agent will be released from the dosage form at a rate that releases a therapeutically effective amount of active agent to the subject baycip 500 comprimidos viagra a substantial portion of the period between administration of the dosage forms. Typically, release will occur over 40 of the period between repeated administration of the dosage form, more preferably at least over 60 of glucosaamina period, and most preferably over 80 of the period. In an especially preferred embodiment, the invention comprises porous particles in which is sorbed liquid, active agent formulation dispersed in a polymer composition having from about 10 weight percent to about 50 weight percent of a water-soluble, high molecular weight polyethylene oxide polymer and from about 10 weight percent ccondroitina about 60 weight percent of a water-insoluble hydroxypropyl cellulose jsm. The polyethylene oxide polymer has a molecular weight of between about 100,000 and condroitona grams per mole. The hydroxypropyl cellulose polymer preferably has a hydroxypropyl content of between about 8-15 weight percent, and most preferably between about 10-13 weight percent. The following examples are illustrative of the gastric retentive embodiment of the present invention.

Detailed information

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Those materials, which are amorphous, typically have a specific surface area (area) of about 100-300 m 2 g, an oil absorption capacity of about 1. 3- 3. 4 mlg, a mean particle size of about 1-2 microns, an angle of repose about 25¬ -45¬, a specific gravity of about 2 gml and a specific volume of about 2. 1-12 mlg. Other materials having similar physical characteristics to the foregoing ranges for FujiCalin and Neusilin may be equivalently substituted for the foregoing, as may blends of the various materials described.

NovaDel Pharma Inc. Notes to Condensed Financial Statements. Note 1 150; Basis of Presentation. The accompanying unaudited condensed financial statements of NovaDel Pharma Inc.]