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Detailed information

7 mlg. The liquid forming the paste with the particles could be the same liquid as the liquid of the liquid, active agent formulation. The completed dosage forms permit the delivery of the active agent to the site of action in the liquid state, thus providing minimal delay in the onset of the desired beneficial effect of the active agent since the active agent does not have to be initially dissolved or dispersed in the form of microparticles at the site of action. Certain magnesium aluminometasilicate powders, sold under the trademark Neusilin, or blends of FujiCalin and Neusilin, may also be utilized to afford dosage forms of the present invention.

The dosage forms so prepared are retained in the stomach of a dog and deliver active agent over a prolonged period of time. In relation to the third embodiment of the present invention exemplified by Figures 6 and 7, they are best understood by reference to the following definitions, the drawings and exemplary disclosure provided herein. Definitions By "active agent", "drug", or "compound", which are used interchangeably herein, is meant an agentdrug, compound, composition of matter or mixture thereof which provides some physiological, psychological, biological, or pharmacological, and often beneficial, effect when in the environment of use. By "uniform rate of release" or "uniform release rate" is meant a rate of release of the active agent from a dosage form that does not vary positively or negatively by more than 30 from the mean rate of release of the active agent over a prolonged period of time, as determined in a USP Type 7 Interval Release Apparatus.

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