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If the applicant has provided a paragraph IV certification to the FDA, the applicant must also send notice of the paragraph IV certification to the NDA holder and patent owner once the NDA has been accepted for filing by the FDA. The NDA holder and patent owner may then initiate a legal challenge to the paragraph IV certification. The filing of a patent infringement lawsuit within 45 days of their receipt of a paragraph IV certification automatically prevents the FDA from approving the Section 505(b)(2) NDA until the earliest of 30 months, expiration of the patent, settlement of the lawsuit or a decision in an infringement case that is favorable to the Section 505(b)(2) applicant. Thus, a Section 505(b)(2) applicant may invest a significant amount of time and expense in the development of its products only to be subject to significant delay and patent litigation before its products may be commercialized.

Correspondent Tim Schwabedissen, 5-4-10] 79,501-dwt German container MV CMA CGM Verlaine (IMO 9221815) collided with 25,638-dwt Israeli Malta-flagged container MV Odessa Star (IMO 9223746, maanged by Zim Integrated Shipping Services, Ltd. ) in dense fog in the Gulf of Izmit, Turkey on Apr. CMA CGM Verlaine suffered a large hole portside, 5 containers fell overboard, 2 sank.]